Mission Six consists of lead vocalist Noah Hayden, bass player Michael Powers, drummer David Horner, keyboardist Isaac Alling, and lead guitarist Lucas Ball. The band was formed in Evansville, Indiana in 2005 when they were just in 5th grade.

Noah, Isaac, Michael, and David grew up together playing sports and went to the same Christian school. Knowing that they all had instrumental abilities and a desire to serve God, they started Mission Six. The band name reflects their mission to put God, their "sixth band member," first.

Noah and David's fathers were both senior pastors, so they practiced at their church. Lucas Ball then joined the band in 2012. The band said later in an iShine interview that Lucas joined the band as a result of their paths crossing together. They were in need of a new guitar player due to former guitarist Anthony Barthel's departure, and found Lucas at an Olive Garden restaurant. He was their waiter. Lucas had grown up in the same town and served in the same church as the boys.

Mission Six was first featured on Radio Disney. They starred in the iShine KNECT TV show with the rest of the iShine Artists, such as The Rubyz, Jamie Grace, Rachel Chan, Spencer Kane, and Tate Huesman.

Their first album, Superhero, was released with Bema Media in July 2008. This was followed up by Not Too Young (2009), Heaven Down To Earth (2012), and Into The Unknown (2015).